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Protein FULL name:
apurinic/apyrimidinic (AP) lyase 2
Protein SHORT name:
Apn2p (Saccharomyces cerevisiae) is product of expression of APN2 gene.
Apn2p is involved in:
BER in Saccharomyces cerevisiae
FUNCTION: DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA.
CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
SUBCELLULAR LOCATION: Nucleus.
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the DNA repair enzymes AP/exoA family.
Links to other databases:
Apn2p (Saccharomyces cerevisiae) is able to recognize following damages:
Apn2p (Saccharomyces cerevisiae) belongs to following protein families:
Last modification of this entry: Oct. 16, 2010.
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