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Protein FULL name:
DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia
Hnt3p (Saccharomyces cerevisiae) is product of expression of HNT3 gene.
Hnt3p is involved in:
BER in Saccharomyces cerevisiae
FUNCTION: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non- ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined.
INTERACTION: P53969:SAM50; NbExp=1; IntAct=EBI-30129, EBI-28646;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
DOMAIN: The HIT domain is required for enzymatic activity (By similarity).
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
SIMILARITY: Contains 1 HIT domain.
Links to other databases:
Hnt3p (Saccharomyces cerevisiae) is able to recognize following damages:
Hnt3p (Saccharomyces cerevisiae) belongs to following protein families:
Last modification of this entry: Oct. 12, 2010.
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