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Protein FULL name:
Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
Ogg1p (Saccharomyces cerevisiae) is product of expression of OGG1 gene.
Ogg1p is involved in:
BER in Saccharomyces cerevisiae
FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.
CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
SUBCELLULAR LOCATION: Nucleus.
MISCELLANEOUS: Present with 3690 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the type-1 OGG1 family.
Links to other databases:
Ogg1p (Saccharomyces cerevisiae) is able to recognize following damages:
Ogg1p (Saccharomyces cerevisiae) belongs to following protein families:
Last modification of this entry: Oct. 14, 2010.
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