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Heteroduplex DNA with single strand protected by RPA (5' directed, distant site)
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Reaction | Previous state | Following state |
RPA protects single stranded DNA (5' directed) in Homo sapiens | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex and ExoI, with partially excised errorenous strand in Homo sapiens | Heteroduplex DNA with single strand protected by RPA (5' directed, distant site) in Homo sapiens |
Reaction | Previous state | Following state |
ExoI excises erroneous strand some distance beyond the mismatch (5' directed) in Homo sapiens | Heteroduplex DNA with single strand protected by RPA (5' directed, distant site) in Homo sapiens | Heteroduplex DNA with removed mismatch (5' directed MMR) in Homo sapiens |