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  Heteroduplex DNA with single strand protected by RPA (5' directed, proximal site) 
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| Reaction | Previous state | Following state | 
| RPA protects single stranded DNA (5' directed, proximal site) in Homo sapiens | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex and ExoI, with partially excised errorenous strand (proximal site) in Homo sapiens | Heteroduplex DNA with single strand protected by RPA (5' directed, proximal site) in Homo sapiens | 
| Reaction | Previous state | Following state | 
| ExoI excises erroneous strand some distance beyond the mismatch (5' directed, proximal site) in Homo sapiens | Heteroduplex DNA with single strand protected by RPA (5' directed, proximal site) in Homo sapiens | Heteroduplex DNA with removed mismatch (5' directed MMR, proximal site) in Homo sapiens | 
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