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Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex
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Reaction | Previous state | Following state |
MutLalpha nicks heteroduplex DNA with nick 5' to mismatch in Saccharomyces cerevisiae | Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha-MutLalpha complex in Saccharomyces cerevisiae | Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Saccharomyces cerevisiae |
Reaction | Previous state | Following state |
ExoI loads onto heteroduplex DNA with nick 5' to mismatch (distant site) in Saccharomyces cerevisiae | Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Saccharomyces cerevisiae | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) in Saccharomyces cerevisiae |
ExoI loads onto heteroduplex DNA with nick 5' to mismatch (on proximal site) in Saccharomyces cerevisiae | Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Saccharomyces cerevisiae | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (proximal site) in Saccharomyces cerevisiae |