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XRCC2X-ray repair complementing defective repair in Chinese hamster cells 2 |
Known also as: DKFZp781P0919;
| NCBI Gene ID: | 7516 |
| NCBI Ensembl Id: | ENSG00000196584 |
| MIM Id: (from NCBI OMIM database) | 600375 |
| Species: | Homo sapiens |
| This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
Diseases related to this gene:
References:
| Authors | Title | Journal |
| Cartwright R, Tambini CE, Simpson PJ, Thacker J | The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. | Nucleic Acids Res July 1, 1998 |
| Cui X, Brenneman M, Meyne J, Oshimura M, Goodwin EH, Chen DJ | The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. | Mutat Res June 23, 1999 |
| Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J | Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. | Breast Cancer Res Treat May 23, 2010 |
| Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert M, Aldape K, Xing J, Wu X, Wei Q, Bondy ML | Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. | Carcinogenesis July 7, 2010 |
| Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF | Variation within DNA repair pathway genes and risk of multiple sclerosis. | Am J Epidemiol July 15, 2010 |
Last modification of this entry: Oct. 6, 2010.
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