Welcome! Click here to login or here to register.
 |
|||||||||||||||||||
|
|||||||||||||||||||
 |
|||||||||||||||||||
RAD1RAD1 homolog (S. pombe) |
Known also as: REC1; HRAD1;
| NCBI Gene ID: | 5810 |
| NCBI Ensembl Id: | ENSG00000113456 |
| MIM Id: (from NCBI OMIM database) | 603153 |
| Species: | Homo sapiens |
| This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Parker AE, Van de Weyer I, Laus MC, Oostveen I, Yon J, Verhasselt P, Luyten WH | A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. | J Biol Chem July 17, 1998 |
| Freire R, Murguia JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP | Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. | Genes Dev Aug. 15, 1998 |
| St Onge RP, Udell CM, Casselman R, Davey S | The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. | Mol Biol Cell June 1, 1999 |
| Zou L, Elledge SJ | Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. | Science June 6, 2003 |
Last modification of this entry: Oct. 6, 2010.
Add your own comment!
There is no comment yet.
|
|
|
|