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CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1) |
Known also as: P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1;
| NCBI Gene ID: | 1026 |
| NCBI Ensembl Id: | ENSG00000124762 |
| MIM Id: (from NCBI OMIM database) | 116899 |
| Species: | Homo sapiens |
| This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
Last modification of this entry: Oct. 13, 2010.
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