Welcome! Click here to login or here to register.
 |
|||||||||||||||||||
|
|||||||||||||||||||
 |
|||||||||||||||||||
REV1REV1 homolog (S. cerevisiae) |
Known also as: REV1L; FLJ21523; MGC26225; MGC163283;
| NCBI Gene ID: | 51455 |
| NCBI Ensembl Id: | ENSG00000135945 |
| MIM Id: (from NCBI OMIM database) | 606134 |
| Species: | Homo sapiens |
| This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M | Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. | J Biol Chem Sept. 21, 2001 |
| Hara K, Hashimoto H, Murakumo Y, Kobayashi S, Kogame T, Unzai S, Akashi S, Takeda S, Shimizu T, Sato M | Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. | J Biol Chem April 16, 2010 |
| Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC | A Large-scale genetic association study of esophageal adenocarcinoma risk. | Carcinogenesis July 1, 2010 |
Last modification of this entry: Oct. 6, 2010.
Add your own comment!
There is no comment yet.
|
|
|
|