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MDC1
mediator of DNA-damage checkpoint 1
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On chromosome: 6p21.3
Known also as: NFBD1; KIAA0170; MGC166888; DKFZp781A0122;
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq]
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Gene sequence:
Proteins coded by this gene:
References:
Authors
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Title
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Journal
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Bakkenist CJ, Kastan MB
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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
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Nature
Feb. 1, 2003
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Polci R, Peng A, Chen PL, Riley DJ, Chen Y
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NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.
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Cancer Res
Dec. 15, 2004
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Miele A, Medina R, van Wijnen AJ, Stein GS, Stein JL
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The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.
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J Cell Biochem
Sept. 1, 2007
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Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J
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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.
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Cell
Nov. 1, 2007
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Last modification of this entry: Oct. 6, 2010.
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