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ALKBH3alkB, alkylation repair homolog 3 (E. coli) |
Known also as: ABH3; PCA1; DEPC1; DEPC-1; FLJ43614; MGC118790; MGC118792; MGC118793;
| NCBI Gene ID: | 221120 |
| NCBI Ensembl Id: | ENSG00000166199 |
| MIM Id: (from NCBI OMIM database) | 610603 |
| Species: | Homo sapiens |
| The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
Diseases related to this gene:
References:
| Authors | Title | Journal |
| Duncan T, Trewick SC, Koivisto P, Bates PA, Lindahl T, Sedgwick B | Reversal of DNA alkylation damage by two human dioxygenases. | Proc Natl Acad Sci U S A Dec. 24, 2002 |
| Sundheim O, Vagbo CB, Bjoras M, Sousa MM, Talstad V, Aas PA, Drablos F, Krokan HE, Tainer JA, Slupphaug G | Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. | EMBO J July 26, 2006 |
Last modification of this entry: Oct. 6, 2010.
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