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TREX1three prime repair exonuclease 1 |
Known also as: CRV; AGS1; DRN3; HERNS; DKFZp434J0310;
| NCBI Gene ID: | 11277 |
| NCBI Ensembl Id: | ENSG00000213689 |
| MIM Id: (from NCBI OMIM database) | 606609 |
| Species: | Homo sapiens |
| This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Hoss M, Robins P, Naven TJ, Pappin DJ, Sgouros J, Lindahl T | A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein. | EMBO J July 1, 1999 |
| Mazur DJ, Perrino FW | Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. | J Biol Chem July 9, 1999 |
| Mazur DJ, Perrino FW | Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. | J Biol Chem May 4, 2001 |
| Yoshioka K, Yoshioka Y, Hsieh P | ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. | Mol Cell May 19, 2006 |
Last modification of this entry: Oct. 6, 2010.
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