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SMUG1single-strand-selective monofunctional uracil-DNA glycosylase 1 |
Known also as: FDG; UNG3; HMUDG; MGC104370;
| NCBI Gene ID: | 23583 |
| NCBI Ensembl Id: | ENSG00000123415 |
| MIM Id: (from NCBI OMIM database) | 607753 |
| Species: | Homo sapiens |
| SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair.[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Lindahl T, Wood RD | Quality control by DNA repair. | Science Dec. 3, 1999 |
| Boorstein RJ, Cummings A Jr, Marenstein DR, Chan MK, Ma Y, Neubert TA, Brown SM, Teebor GW | Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1. | J Biol Chem Nov. 9, 2001 |
| Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G | hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. | J Biol Chem Oct. 18, 2002 |
| Masaoka A, Matsubara M, Hasegawa R, Tanaka T, Kurisu S, Terato H, Ohyama Y, Karino N, Matsuda A, Ide H | Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions. | Biochemistry May 6, 2003 |
| Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | Towards a proteome-scale map of the human protein-protein interaction network. | Nature Oct. 20, 2005 |
Last modification of this entry: Oct. 6, 2010.
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