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XRCC3
X-ray repair complementing defective repair in Chinese hamster cells 3
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On chromosome: 14q32.3
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This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq]
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Tebbs RS, Zhao Y, Tucker JD, Scheerer JB, Siciliano MJ, Hwang M, Liu N, Legerski RJ, Thompson LH
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Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.
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Proc Natl Acad Sci U S A
July 3, 1995
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Cui X, Brenneman M, Meyne J, Oshimura M, Goodwin EH, Chen DJ
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The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells.
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Mutat Res
June 23, 1999
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Bennett BT, Knight KL
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Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.
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J Cell Biochem
Dec. 15, 2005
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Last modification of this entry: Oct. 6, 2010.
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