REPAIRtoire - a database of DNA repair pathways

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XRCC3

X-ray repair complementing defective repair in Chinese hamster cells 3

On chromosome: 14q32.3

NCBI Gene ID: 7517
NCBI Ensembl Id: ENSG00000126215
MIM Id: (from NCBI OMIM database) 600675
Species: Homo sapiens

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Tebbs RS, Zhao Y, Tucker JD, Scheerer JB, Siciliano MJ, Hwang M, Liu N, Legerski RJ, Thompson LH Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. Proc Natl Acad Sci U S A July 3, 1995
Cui X, Brenneman M, Meyne J, Oshimura M, Goodwin EH, Chen DJ The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. Mutat Res June 23, 1999
Bennett BT, Knight KL Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. J Cell Biochem Dec. 15, 2005

Last modification of this entry: Oct. 6, 2010.

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