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RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) |
Known also as: RECA; BRCC5; HRAD51; RAD51A; HsRad51; HsT16930;
| NCBI Gene ID: | 5888 |
| NCBI Ensembl Id: | ENSG00000051180 |
| MIM Id: (from NCBI OMIM database) | 179617 |
| Species: | Homo sapiens |
| The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
Diseases related to this gene:
References:
| Authors | Title | Journal |
| Benson FE, Stasiak A, West SC | Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. | EMBO J Dec. 1, 1994 |
| Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR | Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. | Nature Nov. 21, 2002 |
| Wesoly J, Agarwal S, Sigurdsson S, Bussen W, Van Komen S, Qin J, van Steeg H, van Benthem J, Wassenaar E, Baarends WM, Ghazvini M, Tafel AA, Heath H, Galjart N, Essers J, Grootegoed JA, Arnheim N, Bezzubova O, Buerstedde JM, Sung P, Kanaar R | Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. | Mol Cell Biol Jan. 1, 2006 |
| Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | Large-scale mapping of human protein-protein interactions by mass spectrometry. | Mol Syst Biol Jan. 1, 2007 |
| Davies OR, Pellegrini L | Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats. | Nat Struct Mol Biol June 1, 2007 |
Last modification of this entry: Oct. 6, 2010.
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