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PARP1poly (ADP-ribose) polymerase 1 |
Known also as: PARP; PPOL; ADPRT; ADPRT1; PARP-1; ADPRT 1; pADPRT-1;
| NCBI Gene ID: | 142 |
| NCBI Ensembl Id: | ENSG00000143799 |
| MIM Id: (from NCBI OMIM database) | 173870 |
| Species: | Homo sapiens |
| This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
Last modification of this entry: Oct. 6, 2010.
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