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NTHL1nth endonuclease III-like 1 (E. coli) |
Known also as: NTH1; OCTS3;
| NCBI Gene ID: | 4913 |
| NCBI Ensembl Id: | ENSG00000065057 |
| MIM Id: (from NCBI OMIM database) | 602656 |
| Species: | Homo sapiens |
| The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Aspinwall R, Rothwell DG, Roldan-Arjona T, Anselmino C, Ward CJ, Cheadle JP, Sampson JR, Lindahl T, Harris PC, Hickson ID | Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III. | Proc Natl Acad Sci U S A Feb. 7, 1997 |
| Lindahl T, Wood RD | Quality control by DNA repair. | Science Dec. 3, 1999 |
| Luna L, Bjoras M, Hoff E, Rognes T, Seeberg E | Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA. | Mutat Res July 25, 2000 |
| Oyama M, Wakasugi M, Hama T, Hashidume H, Iwakami Y, Imai R, Hoshino S, Morioka H, Ishigaki Y, Nikaido O, Matsunaga T | Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen. | Biochem Biophys Res Commun Aug. 13, 2004 |
Last modification of this entry: Oct. 6, 2010.
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