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NTHL1

nth endonuclease III-like 1 (E. coli)

On chromosome: 16p13.3
Known also as: NTH1; OCTS3;


NCBI Gene ID: 4913
NCBI Ensembl Id: ENSG00000065057
MIM Id: (from NCBI OMIM database) 602656
Species: Homo sapiens

The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Aspinwall R, Rothwell DG, Roldan-Arjona T, Anselmino C, Ward CJ, Cheadle JP, Sampson JR, Lindahl T, Harris PC, Hickson ID Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III. Proc Natl Acad Sci U S A Feb. 7, 1997
Lindahl T, Wood RD Quality control by DNA repair. Science Dec. 3, 1999
Luna L, Bjoras M, Hoff E, Rognes T, Seeberg E Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA. Mutat Res July 25, 2000
Oyama M, Wakasugi M, Hama T, Hashidume H, Iwakami Y, Imai R, Hoshino S, Morioka H, Ishigaki Y, Nikaido O, Matsunaga T Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen. Biochem Biophys Res Commun Aug. 13, 2004

Last modification of this entry: Oct. 6, 2010.

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