REPAIRtoire - a database of DNA repair pathways

Welcome! Click here to login or here to register.
DNA damage
Draw a picture

Bujnicki Lab Homepage


nei endonuclease VIII-like 3 (E. coli)

On chromosome: 4q34.3
Known also as: FGP2; FPG2; NEI3; hFPG2; hNEI3; FLJ10858;

NCBI Gene ID: 55247
NCBI Ensembl Id: ENSG00000109674
MIM Id: (from NCBI OMIM database) 608934
Species: Homo sapiens

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM]

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Morland I, Rolseth V, Luna L, Rognes T, Bjoras M, Seeberg E Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA. Nucleic Acids Res Nov. 15, 2002
Takao M, Oohata Y, Kitadokoro K, Kobayashi K, Iwai S, Yasui A, Yonei S, Zhang QM Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant. Genes Cells Jan. 1, 2009
Krokeide SZ, Bolstad N, Laerdahl JK, Bjoras M, Luna L Expression and purification of NEIL3, a human DNA glycosylase homolog. Protein Expr Purif June 1, 2009

Last modification of this entry: Oct. 6, 2010.

Add your own comment!

There is no comment yet.
Welcome stranger! Click here to login or here to register.
Valid HTML 4.01! This site is Emacs powered. Made with Django.