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NEIL3nei endonuclease VIII-like 3 (E. coli) |
Known also as: FGP2; FPG2; NEI3; hFPG2; hNEI3; FLJ10858;
| NCBI Gene ID: | 55247 |
| NCBI Ensembl Id: | ENSG00000109674 |
| MIM Id: (from NCBI OMIM database) | 608934 |
| Species: | Homo sapiens |
| NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Morland I, Rolseth V, Luna L, Rognes T, Bjoras M, Seeberg E | Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA. | Nucleic Acids Res Nov. 15, 2002 |
| Takao M, Oohata Y, Kitadokoro K, Kobayashi K, Iwai S, Yasui A, Yonei S, Zhang QM | Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant. | Genes Cells Jan. 1, 2009 |
| Krokeide SZ, Bolstad N, Laerdahl JK, Bjoras M, Luna L | Expression and purification of NEIL3, a human DNA glycosylase homolog. | Protein Expr Purif June 1, 2009 |
Last modification of this entry: Oct. 6, 2010.
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