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CDK7cyclin-dependent kinase 7 |
Known also as: CAK1; MO15; STK1; CDKN7; p39MO15;
| NCBI Gene ID: | 1022 |
| NCBI Ensembl Id: | ENSG00000134058 |
| MIM Id: (from NCBI OMIM database) | 601955 |
| Species: | Homo sapiens |
| The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, Simmons A, Naylor SL, Leach RJ, Lewis TB, et al. | Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. | Oncogene July 1, 1994 |
| Kershnar E, Wu SY, Chiang CM | Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. | J Biol Chem Dec. 18, 1998 |
| Busso D, Keriel A, Sandrock B, Poterszman A, Gileadi O, Egly JM | Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. | J Biol Chem July 28, 2000 |
| Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM | Negative modulation of androgen receptor transcriptional activity by Daxx. | Mol Cell Biol Dec. 1, 2004 |
Last modification of this entry: Oct. 6, 2010.
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