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Bujnicki Lab Homepage

CHEK1

CHK1 checkpoint homolog (S. pombe)

On chromosome: 11q24-q24
Known also as: CHK1;


NCBI Gene ID: 1111
NCBI Ensembl Id: ENSG00000149554
MIM Id: (from NCBI OMIM database) 603078
Species: Homo sapiens

Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science Sept. 5, 1997
Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science Sept. 5, 1997
Zhao H, Watkins JL, Piwnica-Worms H Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc Natl Acad Sci U S A Nov. 12, 2002
Arlander SJ, Felts SJ, Wagner JM, Stensgard B, Toft DO, Karnitz LM Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones. J Biol Chem Jan. 3, 2006
Zhang YW, Brognard J, Coughlin C, You Z, Dolled-Filhart M, Aslanian A, Manning G, Abraham RT, Hunter T The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell Aug. 28, 2009

Last modification of this entry: Oct. 6, 2010.

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