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OGG18-oxoguanine DNA glycosylase |
Known also as: HMMH; MUTM; OGH1; HOGG1;
| NCBI Gene ID: | 4968 |
| NCBI Ensembl Id: | ENSG00000114026 |
| MIM Id: (from NCBI OMIM database) | 601982 |
| Species: | Homo sapiens |
| This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Radicella JP, Dherin C, Desmaze C, Fox MS, Boiteux S | Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. | Proc Natl Acad Sci U S A July 22, 1997 |
| Lindahl T, Wood RD | Quality control by DNA repair. | Science Dec. 3, 1999 |
| Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | Large-scale mapping of human protein-protein interactions by mass spectrometry. | Mol Syst Biol Jan. 1, 2007 |
Last modification of this entry: Oct. 6, 2010.
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