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Bujnicki Lab Homepage

C19orf40

chromosome 19 open reading frame 40

On chromosome: 19q13.11
Known also as: FAAP24; FLJ46828; MGC32020;


NCBI Gene ID: 91442
NCBI Ensembl Id: ENSG00000131944
MIM Id: (from NCBI OMIM database) 610884
Species: Homo sapiens

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Ciccia A, Ling C, Coulthard R, Yan Z, Xue Y, Meetei AR, Laghmani el H, Joenje H, McDonald N, de Winter JP, Wang W, West SC Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell Jan. 9, 2007
Gari K, Decaillet C, Stasiak AZ, Stasiak A, Constantinou A The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol Cell Feb. 18, 2008
Kim JM, Kee Y, Gurtan A, D'Andrea AD Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood May 15, 2008
Collis SJ, Ciccia A, Deans AJ, Horejsi Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell Nov. 7, 2008
Huang M, Kim JM, Shiotani B, Yang K, Zou L, D'Andrea AD The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol Cell July 1, 2010

Last modification of this entry: Oct. 6, 2010.

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