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C19orf40chromosome 19 open reading frame 40 |
Known also as: FAAP24; FLJ46828; MGC32020;
| NCBI Gene ID: | 91442 |
| NCBI Ensembl Id: | ENSG00000131944 |
| MIM Id: (from NCBI OMIM database) | 610884 |
| Species: | Homo sapiens |
| FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Ciccia A, Ling C, Coulthard R, Yan Z, Xue Y, Meetei AR, Laghmani el H, Joenje H, McDonald N, de Winter JP, Wang W, West SC | Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. | Mol Cell Jan. 9, 2007 |
| Gari K, Decaillet C, Stasiak AZ, Stasiak A, Constantinou A | The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. | Mol Cell Feb. 18, 2008 |
| Kim JM, Kee Y, Gurtan A, D'Andrea AD | Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. | Blood May 15, 2008 |
| Collis SJ, Ciccia A, Deans AJ, Horejsi Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ | FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. | Mol Cell Nov. 7, 2008 |
| Huang M, Kim JM, Shiotani B, Yang K, Zou L, D'Andrea AD | The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. | Mol Cell July 1, 2010 |
Last modification of this entry: Oct. 6, 2010.
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