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XRCC4
X-ray repair complementing defective repair in Chinese hamster cells 4
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On chromosome: 5q13-q14
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The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq]
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M, Lieber MR
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Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells.
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Nature
July 31, 1997
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Critchlow SE, Bowater RP, Jackson SP
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Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.
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Curr Biol
Aug. 1, 1997
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Leon DA, Chenet L, Shkolnikov VM, Zakharov S, Shapiro J, Rakhmanova G, Vassin S, McKee M
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Huge variation in Russian mortality rates 1984-94: artefact, alcohol, or what?
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Lancet
Aug. 9, 1997
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Lee JW, Yannone SM, Chen DJ, Povirk LF
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Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.
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Cancer Res
Feb. 1, 2003
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Ahnesorg P, Smith P, Jackson SP
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XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.
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Cell
Feb. 27, 2006
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Last modification of this entry: Oct. 6, 2010.
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