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XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) |
Known also as: KU80; KUB2; Ku86; NFIV; KARP1; KARP-1; FLJ39089;
| NCBI Gene ID: | 7520 |
| NCBI Ensembl Id: | ENSG00000079246 |
| MIM Id: (from NCBI OMIM database) | 194364 |
| Species: | Homo sapiens |
| The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Wedrychowski A, Henzel W, Huston L, Paslidis N, Ellerson D, McRae M, Seong D, Howard OM, Deisseroth A | Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells. | J Biol Chem March 5, 1992 |
| Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J, et al. | Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. | EMBO J Oct. 17, 1994 |
| Bianchi A, de Lange T | Ku binds telomeric DNA in vitro. | J Biol Chem July 23, 1999 |
| Cooper MP, Machwe A, Orren DK, Brosh RM, Ramsden D, Bohr VA | Ku complex interacts with and stimulates the Werner protein. | Genes Dev April 15, 2000 |
| Kim E, Li K, Lieu C, Tong S, Kawai S, Fukutomi T, Zhou Y, Wands J, Li J | Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. | J Hepatol Nov. 1, 2008 |
Last modification of this entry: Oct. 6, 2010.
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