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NEIL1nei endonuclease VIII-like 1 (E. coli) |
Known also as: FPG1; NEI1; hFPG1; FLJ22402;
| NCBI Gene ID: | 79661 |
| NCBI Ensembl Id: | ENSG00000140398 |
| MIM Id: (from NCBI OMIM database) | 608844 |
| Species: | Homo sapiens |
| NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Das A, Boldogh I, Lee JW, Harrigan JA, Hegde ML, Piotrowski J, de Souza Pinto N, Ramos W, Greenberg MM, Hazra TK, Mitra S, Bohr VA | The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. | J Biol Chem Sept. 7, 2007 |
Last modification of this entry: Oct. 6, 2010.
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