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RAD18RAD18 homolog (S. cerevisiae) |
Known also as: RNF73;
| NCBI Gene ID: | 56852 |
| NCBI Ensembl Id: | ENSG00000070950 |
| MIM Id: (from NCBI OMIM database) | 605256 |
| Species: | Homo sapiens |
| The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Tateishi S, Sakuraba Y, Masuyama S, Inoue H, Yamaizumi M | Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. | Proc Natl Acad Sci U S A July 5, 2000 |
| Xin H, Lin W, Sumanasekera W, Zhang Y, Wu X, Wang Z | The human RAD18 gene product interacts with HHR6A and HHR6B. | Nucleic Acids Res July 15, 2000 |
| Tsuji Y, Watanabe K, Araki K, Shinohara M, Yamagata Y, Tsurimoto T, Hanaoka F, Yamamura K, Yamaizumi M, Tateishi S | Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. | Genes Cells April 1, 2008 |
Last modification of this entry: Oct. 6, 2010.
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