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Parp1
poly (ADP-ribose) polymerase family, member 1
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On chromosome: 1 98.6 cM
Known also as: PARP; PPOL; Adprp; Adprt1; C80510; parp-1; sPARP-1; AI893648; 5830444G22Rik;
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Mus musculus poly (ADP-ribose) polymerase family, member 1 (Parp1).
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Lebel M
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Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.
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Carcinogenesis
Feb. 1, 2002
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Schreiber V, Ame JC, Dolle P, Schultz I, Rinaldi B, Fraulob V, Menissier-de Murcia J, de Murcia G
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Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.
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J Biol Chem
June 21, 2002
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Benchoua A, Couriaud C, Guegan C, Tartier L, Couvert P, Friocourt G, Chelly J, Menissier-de Murcia J, Onteniente B
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Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2.
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J Biol Chem
Sept. 13, 2002
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Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R
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Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
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Am J Pathol
May 1, 2003
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Simbulan-Rosenthal CM, Rosenthal DS, Luo R, Samara R, Espinoza LA, Hassa PO, Hottiger MO, Smulson ME
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PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.
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Oncogene
Nov. 20, 2003
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Last modification of this entry: Oct. 6, 2010.
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