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CCNHcyclin H |
Known also as: CAK; p34; p37;
| NCBI Gene ID: | 902 |
| NCBI Ensembl Id: | ENSG00000134480 |
| MIM Id: (from NCBI OMIM database) | 601953 |
| Species: | Homo sapiens |
| The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Holstege FC, Fiedler U, Timmers HT | Three transitions in the RNA polymerase II transcription complex during initiation. | EMBO J Dec. 15, 1997 |
| Kershnar E, Wu SY, Chiang CM | Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. | J Biol Chem Dec. 18, 1998 |
| Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | Large-scale mapping of human protein-protein interactions by mass spectrometry. | Mol Syst Biol Jan. 1, 2007 |
Last modification of this entry: Oct. 6, 2010.
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