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ATRIPATR interacting protein |
Known also as: FLJ12343; MGC20625; MGC21482; MGC26740; DKFZp762J2115;
| NCBI Gene ID: | 84126 |
| NCBI Ensembl Id: | ENSG00000164053 |
| MIM Id: (from NCBI OMIM database) | 606605 |
| Species: | Homo sapiens |
| The product of this gene is an essential component of the DNA damage checkpoint, and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Zou L, Elledge SJ | Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. | Science June 6, 2003 |
| Wang Y, Qin J | MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. | Proc Natl Acad Sci U S A Dec. 23, 2003 |
| Clarke CA, Clarke PR | DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. | Biochem J June 1, 2005 |
Last modification of this entry: Oct. 6, 2010.
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