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UNGuracil-DNA glycosylase |
Known also as: DGU; UDG; UNG1; UNG2; HIGM4; UNG15; DKFZp781L1143;
| NCBI Gene ID: | 7374 |
| NCBI Ensembl Id: | ENSG00000076248 |
| MIM Id: (from NCBI OMIM database) | 191525 |
| Species: | Homo sapiens |
| This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
Diseases related to this gene:
References:
| Authors | Title | Journal |
| Mol CD, Arvai AS, Sanderson RJ, Slupphaug G, Kavli B, Krokan HE, Mosbaugh DW, Tainer JA | Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA. | Cell Sept. 8, 1995 |
| Nilsen H, Otterlei M, Haug T, Solum K, Nagelhus TA, Skorpen F, Krokan HE | Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. | Nucleic Acids Res Jan. 15, 1997 |
| Jones KL, Roche M, Gantier MP, Begum NA, Honjo T, Caradonna S, Williams BR, Mak J | X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells. | J Biol Chem June 11, 2010 |
| Arora M, Lindgren B, Basu S, Nagaraj S, Gross M, Weisdorf D, Thyagarajan B | Polymorphisms in the base excision repair pathway and graft-versus-host disease. | Leukemia Aug. 1, 2010 |
Last modification of this entry: Oct. 6, 2010.
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