REPAIRtoire - a database of DNA repair pathways

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Bujnicki Lab Homepage

UNG

uracil-DNA glycosylase

On chromosome: 12q23-q24.1
Known also as: DGU; UDG; UNG1; UNG2; HIGM4; UNG15; DKFZp781L1143;


NCBI Gene ID: 7374
NCBI Ensembl Id: ENSG00000076248
MIM Id: (from NCBI OMIM database) 191525
Species: Homo sapiens

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
Diseases related to this gene:
References:

Authors Title Journal
Mol CD, Arvai AS, Sanderson RJ, Slupphaug G, Kavli B, Krokan HE, Mosbaugh DW, Tainer JA Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA. Cell Sept. 8, 1995
Nilsen H, Otterlei M, Haug T, Solum K, Nagelhus TA, Skorpen F, Krokan HE Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. Nucleic Acids Res Jan. 15, 1997
Jones KL, Roche M, Gantier MP, Begum NA, Honjo T, Caradonna S, Williams BR, Mak J X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells. J Biol Chem June 11, 2010
Arora M, Lindgren B, Basu S, Nagaraj S, Gross M, Weisdorf D, Thyagarajan B Polymorphisms in the base excision repair pathway and graft-versus-host disease. Leukemia Aug. 1, 2010

Last modification of this entry: Oct. 6, 2010.

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