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FEN1flap structure-specific endonuclease 1 |
Known also as: MF1; RAD2; FEN-1;
| NCBI Gene ID: | 2237 |
| NCBI Ensembl Id: | ENSG00000168496 |
| MIM Id: (from NCBI OMIM database) | 600393 |
| Species: | Homo sapiens |
| The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Murray JM, Tavassoli M, al-Harithy R, Sheldrick KS, Lehmann AR, Carr AM, Watts FZ | Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage. | Mol Cell Biol July 1, 1994 |
| Robins P, Pappin DJ, Wood RD, Lindahl T | Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I. | J Biol Chem Nov. 18, 1994 |
| Qiu J, Bimston DN, Partikian A, Shen B | Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination. | J Biol Chem July 5, 2002 |
| Zheng L, Zhou M, Guo Z, Lu H, Qian L, Dai H, Qiu J, Yakubovskaya E, Bogenhagen DF, Demple B, Shen B | Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. | Mol Cell Nov. 7, 2008 |
Last modification of this entry: Oct. 6, 2010.
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