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Mdc1mediator of DNA damage checkpoint 1 |
Known also as: Nfbd1; AA413496; mKIAA0170; 6820401C03;
| NCBI Gene ID: | 240087 |
| NCBI Ensembl Id: | ENSMUSG00000061607 |
| Species: | Mus musculus |
| The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 7 divergent copies of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. Mice with mutations in this gene exhibit growth retardation, male infertility, immune defects, chromosome instability, DNA repair defects, and radiation sensitivity. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
Last modification of this entry: Oct. 6, 2010.
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