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RAD9ARAD9 homolog A (S. pombe) |
Known also as: RAD9;
| NCBI Gene ID: | 5883 |
| NCBI Ensembl Id: | ENSG00000172613 |
| MIM Id: (from NCBI OMIM database) | 603761 |
| Species: | Homo sapiens |
| This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| St Onge RP, Udell CM, Casselman R, Davey S | The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. | Mol Biol Cell June 1, 1999 |
| Bessho T, Sancar A | Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease. | J Biol Chem March 17, 2000 |
| Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D | HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. | J Biol Chem Sept. 8, 2000 |
| Yoshida K, Komatsu K, Wang HG, Kufe D | c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. | Mol Cell Biol May 1, 2002 |
| Lindsey-Boltz LA, Wauson EM, Graves LM, Sancar A | The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD. | Nucleic Acids Res Jan. 1, 2004 |
Last modification of this entry: Oct. 6, 2010.
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