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POLBpolymerase (DNA directed), beta |
Known also as: MGC125976;
| NCBI Gene ID: | 5423 |
| NCBI Ensembl Id: | ENSG00000070501 |
| MIM Id: (from NCBI OMIM database) | 174760 |
| Species: | Homo sapiens |
| In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. Also see POLA (MIM 312040).[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Kubota Y, Nash RA, Klungland A, Schar P, Barnes DE, Lindahl T | Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. | EMBO J Dec. 2, 1996 |
| Conlon KA, Miller H, Rosenquist TA, Zharkov DO, Berrios M | The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. | DNA Repair (Amst) April 4, 2005 |
| El-Andaloussi N, Valovka T, Toueille M, Steinacher R, Focke F, Gehrig P, Covic M, Hassa PO, Schar P, Hubscher U, Hottiger MO | Arginine methylation regulates DNA polymerase beta. | Mol Cell April 7, 2006 |
Last modification of this entry: Oct. 6, 2010.
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