REPAIRtoire - a database of DNA repair pathways

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Bujnicki Lab Homepage

POLB

polymerase (DNA directed), beta

On chromosome: 8p11.2
Known also as: MGC125976;


NCBI Gene ID: 5423
NCBI Ensembl Id: ENSG00000070501
MIM Id: (from NCBI OMIM database) 174760
Species: Homo sapiens

In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. Also see POLA (MIM 312040).[supplied by OMIM]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Kubota Y, Nash RA, Klungland A, Schar P, Barnes DE, Lindahl T Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. EMBO J Dec. 2, 1996
Conlon KA, Miller H, Rosenquist TA, Zharkov DO, Berrios M The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. DNA Repair (Amst) April 4, 2005
El-Andaloussi N, Valovka T, Toueille M, Steinacher R, Focke F, Gehrig P, Covic M, Hassa PO, Schar P, Hubscher U, Hottiger MO Arginine methylation regulates DNA polymerase beta. Mol Cell April 7, 2006

Last modification of this entry: Oct. 6, 2010.

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