REPAIRtoire - a database of DNA repair pathways

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RAD51-like 3 (S. cerevisiae)

On chromosome: 17q11
Known also as: Trad; R51H3; HsTRAD; RAD51D;

NCBI Gene ID: 5892
NCBI Ensembl Id: ENSG00000185379
MIM Id: (from NCBI OMIM database) 602954
Species: Homo sapiens

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Several alternatively spliced transcript variants of this gene have been described, but the biological validity of some of them has not been determined. [provided by RefSeq]

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Pittman DL, Weinberg LR, Schimenti JC Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. Genomics April 1, 1998
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol Jan. 1, 2007
McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Couch FJ, Cunningham JM, Matsumoto ME, Rabe KG, Hammer TJ, Petersen GM Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. Cancer Epidemiol Biomarkers Prev Sept. 1, 2009
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Breast Cancer Res Treat May 23, 2010
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF Variation within DNA repair pathway genes and risk of multiple sclerosis. Am J Epidemiol July 15, 2010

Last modification of this entry: Oct. 6, 2010.

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