REPAIRtoire - a database of DNA repair pathways

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RAD52

RAD52 homolog (S. cerevisiae)

On chromosome: 12p13-p12.2

NCBI Gene ID: 5893
NCBI Ensembl Id: ENSG00000002016
MIM Id: (from NCBI OMIM database) 600392
Species: Homo sapiens

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Shen Z, Denison K, Lobb R, Gatewood JM, Chen DJ The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues. Genomics Feb. 1, 1995
Motycka TA, Bessho T, Post SM, Sung P, Tomkinson AE Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52. J Biol Chem April 2, 2004

Last modification of this entry: Oct. 6, 2010.

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