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NEIL2nei endonuclease VIII-like 2 (E. coli) |
Known also as: NEH2; NEI2; MGC2832; MGC4505; FLJ31644;
| NCBI Gene ID: | 252969 |
| NCBI Ensembl Id: | ENSG00000154328 |
| MIM Id: (from NCBI OMIM database) | 608933 |
| Species: | Homo sapiens |
| NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Zhai X, Zhao H, Liu Z, Wang LE, El-Naggar AK, Sturgis EM, Wei Q | Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. | Clin Cancer Res July 1, 2008 |
| Kinslow CJ, El-Zein RA, Hill CE, Wickliffe JK, Abdel-Rahman SZ | Single nucleotide polymorphisms 5' upstream the coding region of the NEIL2 gene influence gene transcription levels and alter levels of genetic damage. | Genes Chromosomes Cancer Nov. 1, 2008 |
| Grin IR, Rieger RA, Zharkov DO | Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. | Biochem Biophys Res Commun March 26, 2010 |
| Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J | Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. | Breast Cancer Res Treat May 23, 2010 |
| Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF | Variation within DNA repair pathway genes and risk of multiple sclerosis. | Am J Epidemiol July 15, 2010 |
Last modification of this entry: Oct. 6, 2010.
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