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EME1essential meiotic endonuclease 1 homolog 1 (S. pombe) |
Known also as: MMS4L; FLJ31364;
| NCBI Gene ID: | 146956 |
| NCBI Ensembl Id: | ENSG00000154920 |
| MIM Id: (from NCBI OMIM database) | 610885 |
| Species: | Homo sapiens |
| This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants. |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Fekairi S, Scaglione S, Chahwan C, Taylor ER, Tissier A, Coulon S, Dong MQ, Ruse C, Yates JR 3rd, Russell P, Fuchs RP, McGowan CH, Gaillard PH | Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. | Cell July 10, 2009 |
| Loizidou MA, Cariolou MA, Neuhausen SL, Newbold RF, Bashiardes E, Marcou Y, Michael T, Daniel M, Kakouri E, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K | Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. | Breast Cancer Res Treat May 1, 2010 |
| Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert M, Aldape K, Xing J, Wu X, Wei Q, Bondy ML | Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. | Carcinogenesis July 7, 2010 |
| Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF | Variation within DNA repair pathway genes and risk of multiple sclerosis. | Am J Epidemiol July 15, 2010 |
Last modification of this entry: Oct. 6, 2010.
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