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DCLRE1BDNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) |
Known also as: SNM1B; APOLLO; FLJ12810; FLJ13998; DKFZp686C24187;
| NCBI Gene ID: | 64858 |
| NCBI Ensembl Id: | ENSG00000118655 |
| MIM Id: (from NCBI OMIM database) | 609683 |
| Species: | Homo sapiens |
| DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Lenain C, Bauwens S, Amiard S, Brunori M, Giraud-Panis MJ, Gilson E | The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. | Curr Biol July 11, 2006 |
| Liu L, Akhter S, Bae JB, Mukhopadhyay SS, Richie CT, Liu X, Legerski R | SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint. | Cell Cycle Jan. 15, 2009 |
| Anders M, Mattow J, Digweed M, Demuth I | Evidence for hSNM1B/Apollo functioning in the HSP70 mediated DNA damage response. | Cell Cycle June 1, 2009 |
| Ye J, Lenain C, Bauwens S, Rizzo A, Saint-Leger A, Poulet A, Benarroch D, Magdinier F, Morere J, Amiard S, Verhoeyen E, Britton S, Calsou P, Salles B, Bizard A, Nadal M, Salvati E, Sabatier L, Wu Y, Biroccio A, Londono-Vallejo A, Giraud-Panis MJ, Gilson E | TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. | Cell July 23, 2010 |
Last modification of this entry: Oct. 6, 2010.
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