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RAD17RAD17 homolog (S. pombe) |
Known also as: CCYC; R24L; RAD24; HRAD17; RAD17SP; FLJ41520;
| NCBI Gene ID: | 5884 |
| NCBI Ensembl Id: | ENSG00000152942 |
| MIM Id: (from NCBI OMIM database) | 603139 |
| Species: | Homo sapiens |
| The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Parker AE, Van de Weyer I, Laus MC, Verhasselt P, Luyten WH | Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene. | J Biol Chem July 17, 1998 |
| Rauen M, Burtelow MA, Dufault VM, Karnitz LM | The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. | J Biol Chem Sept. 22, 2000 |
| Zou L, Elledge SJ | Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. | Science June 6, 2003 |
| Tsao CC, Geisen C, Abraham RT | Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. | EMBO J Nov. 24, 2004 |
Last modification of this entry: Oct. 6, 2010.
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