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HUS1
HUS1 checkpoint homolog (S. pombe)
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On chromosome: 7p13-p12
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The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. [provided by RefSeq]
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Volkmer E, Karnitz LM
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Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex.
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J Biol Chem
Feb. 8, 1999
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St Onge RP, Udell CM, Casselman R, Davey S
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The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.
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Mol Biol Cell
June 1, 1999
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Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D
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HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.
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J Biol Chem
Sept. 8, 2000
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Zou L, Elledge SJ
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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
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Science
June 6, 2003
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Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
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A Large-scale genetic association study of esophageal adenocarcinoma risk.
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Carcinogenesis
July 1, 2010
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Last modification of this entry: Oct. 6, 2010.
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