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PRKDCprotein kinase, DNA-activated, catalytic polypeptide |
Known also as: HYRC; p350; DNAPK; DNPK1; HYRC1; XRCC7; DNA-PKcs;
| NCBI Gene ID: | 5591 |
| NCBI Ensembl Id: | ENSG00000121031 |
| MIM Id: (from NCBI OMIM database) | 600899 |
| Species: | Homo sapiens |
| The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW, Jackson SP | DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. | Cell Sept. 8, 1995 |
| Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP | DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. | J Biol Chem Feb. 23, 1998 |
| Wang YG, Nnakwe C, Lane WS, Modesti M, Frank KM | Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. | J Biol Chem Sept. 3, 2004 |
| Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS | A role of DNA-PK for the metabolic gene regulation in response to insulin. | Cell March 20, 2009 |
Last modification of this entry: Oct. 6, 2010.
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