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PNKPpolynucleotide kinase 3'-phosphatase |
Known also as: PNK;
| NCBI Gene ID: | 11284 |
| NCBI Ensembl Id: | ENSG00000039650 |
| MIM Id: (from NCBI OMIM database) | 605610 |
| Species: | Homo sapiens |
| The PNKP gene encodes a polynucleotide kinase 3-prime phosphatase, which catalyzes the 5-prime phosphorylation of nucleic acids and also has an associated 3-prime phosphatase activity, predictive of an important function in DNA repair following ionizing radiation or oxidative damage (Jilani et al., 1999 [PubMed 10446192]).[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW, Lasko DD | Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. | J Biol Chem Aug. 20, 1999 |
| Karimi-Busheri F, Daly G, Robins P, Canas B, Pappin DJ, Sgouros J, Miller GG, Fakhrai H, Davis EM, Le Beau MM, Weinfeld M | Molecular characterization of a human DNA kinase. | J Biol Chem Aug. 20, 1999 |
Last modification of this entry: Oct. 6, 2010.
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