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PCNAproliferating cell nuclear antigen |
Known also as: MGC8367;
| NCBI Gene ID: | 5111 |
| NCBI Ensembl Id: | ENSG00000132646 |
| MIM Id: (from NCBI OMIM database) | 176740 |
| Species: | Homo sapiens |
| The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Clark AB, Valle F, Drotschmann K, Gary RK, Kunkel TA | Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes. | J Biol Chem Nov. 24, 2000 |
| Oyama M, Wakasugi M, Hama T, Hashidume H, Iwakami Y, Imai R, Hoshino S, Morioka H, Ishigaki Y, Nikaido O, Matsunaga T | Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen. | Biochem Biophys Res Commun Aug. 13, 2004 |
| Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC Jr | Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. | J Biol Chem Feb. 21, 2005 |
Last modification of this entry: Oct. 6, 2010.
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